Chronic Disease And CancerCondition

Stopping thyroid replacement in a substantial minority

April 6, 2026John Mandrola, MD

John Mandrola reacts to evidence suggesting about one in four patients on thyroid replacement could discontinue therapy, and wonders whether placebo-controlled discontinuation would show even higher rates and apply to other medications.

I, naively, assumed all pts on thyroid replacement needed it.
Gosh, 1 in 4 pts could stop the med
I bet if you used a proper placebo the discontinuation rate would be even higher
John Mandrola, MD
deprescribingendocrinology

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