Vaccines And ImmunizationVaccine Topic

mRNA vaccine biodistribution and persistence testing

April 1, 2026Wafik S. El-Deiry, MD, PhD, FACP

Wafik El-Deiry argues mRNA vaccines should be tested for biodistribution and persistence to ensure potentially pathogenic antigens are appropriately evaluated, reflecting ongoing safety and regulatory scrutiny debates.

Point is if you’re developing an mRNA vaccine without control of biodistribution or persistence, manufacturers and regulators must ensure potentially pathogenic antigens
manufacturers and regulators must ensure potentially pathogenic antigens including those with potential activities to suppress host defenses against cancer are appropriately tested.
Wafik S. El-Deiry, MD, PhD, FACP
vaccine safetymRNAregulation

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