Clinical Research And EvidenceEvidence Item

Memantine NMDA antagonism reduced premature atrial contractions and new onset atrial fibrillation risk

March 30, 2026Circulation

Circulation highlights a phase 2 randomized trial where memantine reduced premature atrial contractions, lowered non sustained atrial tachycardia, and cut new onset atrial fibrillation risk, suggesting a glutamatergic pathway target for atrial arrhythmias.

In a Phase 2 RCT, antagonism of NMDA receptors with memantine reduced premature atrial contractions
lowered non-sustained atrial tachycardia
cut new-onset AF risk, highlighting a novel glutamatergic pathway for atrial arrhythmia therapy.
In a Phase 2 RCT, antagonism of NMDA receptors with memantine reduced premature atrial contractions, lowered non-sustained atrial tachycardia & cut new-onset AF risk, highlighting a novel glutamatergic pathway for atrial arrhythmia therapy.
Circulation
atrial fibrillationdrug repurposingRCT

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