ViralTopic

levothyroxine deprescribing in older adults

April 6, 2026JAMA, John Mandrola, MD

JAMA highlights evidence that many adults 60+ can discontinue levothyroxine while maintaining thyroid function; John Mandrola, MD reacts that he assumed all patients on thyroid replacement needed it.

In adults ≥60 years, 26% discontinued levothyroxine while maintaining thyroid function
with 64% success for doses ≤50 μg/d
Gosh, 1 in 4 pts could stop the med
and no clinically important changes in thyroid-related symptoms.
JAMA
John Mandrola, MD
deprescribingendocrinologygeriatrics

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