Clinical Research And EvidenceFinding

Duloxetine does not prevent oxaliplatin induced peripheral neuropathy

April 4, 2026Cristiane D Bergerot, PhD, FASCO, Maryam Lustberg MD, MPH, FASCO

Cristiane Bergerot and Maryam Lustberg highlight a trial where duloxetine at 30 or 60 mg did not reduce oxaliplatin induced peripheral neuropathy versus placebo, underscoring prevention gaps and placebo effects in symptom trials.

We can treat painful neuropathy, but can we prevent it?
This trial shows duloxetine (30 or 60 mg) did not reduce OIPN vs placebo.
the strong placebo effect in symptom management studies
Cristiane D Bergerot, PhD, FASCO
Maryam Lustberg MD, MPH, FASCO
oncologysupportive care

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