Chronic Disease And CancerCondition

Dato DXd first line for IO ineligible metastatic triple negative breast cancer

April 4, 2026Paolo Tarantino

Paolo Tarantino says Dato-DXd in TROPION-Breast02 nearly doubled progression-free survival and response rate and improved overall survival versus chemotherapy in IO-ineligible metastatic triple negative breast cancer.

TROPION-Breast02 published in Annals_Oncology: 1L therapy with Dato-DXd led to near doubling of PFS, ORR and significant OS benefit (vs chemo) in IO-ineligible mTNBC.
New important option and new hope for one of the most aggressive forms of breast cancer.
Paolo Tarantino
breast cancerADCclinical trial

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