Chronic Disease And CancerCondition

Cancer associated fibroblast subtypes in brain metastases

April 5, 2026Gabriel Zada, MD, MS

Gabriel Zada, MD reports single cell and spatial sequencing identifying four CAF subtypes in brain metastases, including a novel tumor inhibitory ISLR positive population, suggesting targetable tumor microenvironment biology.

Single-cell + spatial sequencing reveals 4 distinct Cancer Associated Fibroblast (CAF) subtypes in brain metastases
including a novel tumor-inhibitory ISLR+ population
highlighting the complex, targetable biology
Gabriel Zada, MD, MS
tumor microenvironmentsingle cell

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