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Trial appraisal criticism is not personal; use Claude to stress-test trial critiques

March 28, 2026John Mandrola, MD

John Mandrola tells fellows to ignore personalizing trial criticism and suggests using Claude to surface “toughest criticisms” when presenting seminal trials.

“Criticism of trials is not personal; it is for our patients”
“Trial appraisal is not personal; it’s LITERALLY our job as evidence-based clinicians”
“Heck…put it into CLAUDE and ask what are the toughest criticisms of this trial”
John Mandrola, MD
mededevidence-based-medicine

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