Clinical Research And EvidenceStudy Finding

OPTIMAL trial IVUS guided PCI in unprotected left main coronary disease

March 31, 2026NEJM, PCRonline

NEJM highlights OPTIMAL comparing IVUS-guided versus angiography-guided PCI in unprotected left main disease, with editorial framing the question of whether IVUS is always necessary.

Original Article: IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease (OPTIMAL trial)
Editorial: Seeing the Left Main Coronary Artery Clearly — Is IVUS Always Necessary?
routine IVUS-guided PCI improves clinical outcomes compared with angiography-guided PCI
NEJM
PCRonline
trialIVUSPCI

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