Clinical Research And EvidenceStudy Finding

Iptacopan complement factor B inhibition in IgA nephropathy

March 29, 2026NEJM, Sayna Norouzi, MD, FASN

NEJM and nephrology conference posts report that iptacopan, a complement factor B inhibitor, significantly slowed kidney-function decline in IgA nephropathy, with final 24-month phase 3 data highlighted.

Alternative complement pathway overactivation contributes to IgA nephropathy.
iptacopan, a complement factor B inhibitor, significantly slowed kidney-function decline in patients with IgA nephropathy.
Original Article: Iptacopan in IgA Nephropathy — Final 24-Month Data (phase 3 APPLAUSE-IgAN trial)
NEJM
Sayna Norouzi, MD, FASN
trialnephrology

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