HI-PEITHO trial ultrasound-facilitated catheter-directed thrombolysis for intermediate-risk PE

“ultrasound-facilitated, catheter-directed fibrinolysis led to a lower risk of a composite of major adverse outcomes than anticoagulation alone.”

“↓ Early clinical deterioration: 4.0% vs 10.3%”

“HI-PEITHO trial just dropped: US-facilitated thrombolysis vs anticoagulation alone in intermediate-risk acute PE”

“~18 mg alteplase over 7 hrs is safe (no ICH, no difference in bleeding rates)”

“HI-PEITHO was built off of the ESC risk-stratification system and it's impossible to map these patients onto the AHA/ACC classification”

ultrasound-facilitated, catheter-directed fibrinolysis led to a lower risk of a composite of major adverse outcomes than anticoagulation alone.

↓ Early clinical deterioration: 4.0% vs 10.3%

HI-PEITHO trial just dropped: US-facilitated thrombolysis vs anticoagulation alone in intermediate-risk acute PE

~18 mg alteplase over 7 hrs is safe (no ICH, no difference in bleeding rates)

ultrasound-facilitated, catheter-directed fibrinolysis led to a lower risk of a composite of major adverse outcomes

Intermediate-risk PE = stable patients with RV strain + positive biomarkers