Clinical Research And EvidenceEvidence

ALL-RISE / FFRangio noninferiority vs pressure-wire guidance for intermediate coronary stenosis

March 29, 2026NEJM, Dr. Martha Gulati, Dr Shariq Shamim

NEJM and interventional cardiology commentators report angiography-derived physiology (FFRangio) was noninferior to pressure-wire guidance, fueling calls to adopt faster wire-free assessment in the cath lab.

In the ALL-RISE trial, FFRangio (fractional flow reserve derived from angiography) was noninferior to pressure-wire–guided assessment
Do we still need pressure wires to guide PCI?
Aptly named ALL RISE trial at #ACC26. Wire based FFR vs conventional Angiogram based FFR.
With non-inferiority of trial, probably it's time to quickly adopt the angiogram based FFR and move away
ALL RISE: FFRangio is noninferior to pressure-wire–guided assessment
NEJM
Dr. Martha Gulati
Dr Shariq Shamim
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cardiologydiagnosticsnoninferiority

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